Low-dose chest computed tomography (LDCT) inherently captures both pulmonary and cardiac structures, offering a unique opportunity for joint assessment of lung and cardiovascular health. However, most existing approaches treat these domains as independent tasks, overlooking their physiological interplay and shared imaging biomarkers. We propose an Explainable Cross-Disease Reasoning Framework that enables interpretable cardiopulmonary risk assessment from a single LDCT scan. The framework introduces an agentic reasoning process that emulates clinical diagnostic thinking-first perceiving pulmonary findings, then reasoning through established medical knowledge, and finally deriving a cardiovascular judgment with explanatory rationale. It integrates three synergistic components: a pulmonary perception module that summarizes lung abnormalities, a knowledge-guided reasoning module that infers their cardiovascular implications, and a cardiac representation module that encodes structural biomarkers. Their outputs are fused to produce a holistic cardiovascular risk prediction that is both accurate and physiologically grounded. Experiments on the NLST cohort demonstrate that the proposed framework achieves state-of-the-art performance for CVD screening and mortality prediction, outperforming single-disease and purely image-based baselines. Beyond quantitative gains, the framework provides human-verifiable reasoning that aligns with cardiological understanding, revealing coherent links between pulmonary abnormalities and cardiac stress mechanisms. Overall, this work establishes a unified and explainable paradigm for cardiovascular analysis from LDCT, bridging the gap between image-based prediction and mechanism-based medical interpretation.

Charges against an American influencer and teen pilot who has been stranded on a remote island in the Antarctic since June have been dropped. Ethan Guo, 19, is alleged to have illegally landed his plane in Chilean territory after embarking on a solo trip to all seven continents to raise money for cancer research, according to local authorities. They accused him of providing false flight plan information to officials who detained him and opened an investigation. A judge has ordered him to leave the area, pay a $30,000 (£22,332) donation to a children's cancer foundation and is banned from re-entering Chilean territory for three years. Mr Guo made headlines last year when he began an attempt to become the youngest person to fly solo to all seven continents and collect donations for research into childhood cancer.

Protein design with desirable properties has been a significant challenge for many decades. Generative artificial intelligence is a promising approach and has achieved great success in various protein generation tasks. Notably, diffusion models stand out for their robust mathematical foundations and impressive generative capabilities, offering unique advantages in certain applications such as protein design. In this review, we first give the definition and characteristics of diffusion models and then focus on two strategies: Denoising Diffusion Probabilistic Models and Score-based Generative Models, where DDPM is the discrete form of SGM. Furthermore, we discuss their applications in protein design, peptide generation, drug discovery, and protein-ligand interaction. Finally, we outline the future perspectives of diffusion models to advance autonomous protein design and engineering. The E(3) group consists of all rotations, reflections, and translations in three-dimensions. The equivariance on the E(3) group can keep the physical stability of the frame of each amino acid as much as possible, and we reflect on how to keep the diffusion model E(3) equivariant for protein generation.

In this thesis, we investigated the relevance, faithfulness, and succinctness aspects of Long Form Question Answering (LFQA). LFQA aims to generate an in-depth, paragraph-length answer for a given question, to help bridge the gap between real scenarios and the existing open-domain QA models which can only extract short-span answers. LFQA is quite challenging and under-explored. Few works have been done to build an effective LFQA system. It is even more challenging to generate a good-quality long-form answer relevant to the query and faithful to facts, since a considerable amount of redundant, complementary, or contradictory information will be contained in the retrieved documents. Moreover, no prior work has been investigated to generate succinct answers. We are among the first to research the LFQA task. We pioneered the research direction to improve the answer quality in terms of 1) query-relevance, 2) answer faithfulness, and 3) answer succinctness.

The expedition to find the wreck of Sir Ernest Shackleton's Endurance is set to sail next month, it was announced today on the centenary of the polar explorer's death. Endurance was one of two ships used by the Imperial Trans-Antarctic expedition of 1914–1917, which hoped to make the first land crossing of the Antarctic. Carrying an expedition crew of 28 men, the 144-foot-long Endurance was a three-masted schooner barque sturdily built for operations in polar waters. Aiming to land at Vahsel Bay, the vessel became stuck in pack ice on the Weddell Sea on January 18, 1915 -- where she and her crew would remain for many months. In late October, however, a drop in temperature from 42 F to -14 F saw the ice pack begin to steadily crush the Endurance, which finally sank on November 21, 1915.

In this paper we provide a comprehensive introduction to knowledge graphs, which have recently garnered significant attention from both industry and academia in scenarios that require exploiting diverse, dynamic, large-scale collections of data. After a general introduction, we motivate and contrast various graph-based data models and query languages that are used for knowledge graphs. We discuss the roles of schema, identity, and context in knowledge graphs. We explain how knowledge can be represented and extracted using a combination of deductive and inductive techniques. We summarise methods for the creation, enrichment, quality assessment, refinement, and publication of knowledge graphs. We provide an overview of prominent open knowledge graphs and enterprise knowledge graphs, their applications, and how they use the aforementioned techniques. We conclude with high-level future research directions for knowledge graphs.

NASA has spotted a gigantic new iceberg three times the size of Manhattan in Antarctica. Named B-46, it is believed to measure 66 square nautical miles (87 square miles), according to estimates from the U.S. National Ice Center. NASA's Operation IceBridge flight spotted the giant berg, which broke off from Pine Island Glacier in late October. Wednesday's flight plan took the IceBridge team over Pine Island Glacier as part of the long-running campaign to collect year-over-year measurements of sea ice, glaciers, and critical regions of Earth's ice sheets. 'As NASA's DC-8 flew its pre-determined flight pattern, the new iceberg that calved in late October came into view,' the Space Agency said.

NASA has spotted a second perfectly rectangular iceberg in the Antarctic. The second rectangular berg, known as a'tabular' iceberg, was spotted off the east coast of the Antarctic Peninsula, near the Larsen C ice shelf and close to the first one. It is part of a large'field of bergs NASA experts may have recently broken off the shelf, and say the sharp angles and flat surfaces are evidence the break occurred very recently. Just past the original rectangular iceberg, which is visible from behind the outboard engine, IceBridge saw another relatively rectangular berg and the A68 iceberg in the distance. Tabular icebergs split off the edges of ice shelves in the same way a fingernail that grows too long ends up cracking off.

The TRW Defense Systems Group develops large man-machine networks that solve problems for government agencies. Until a few years ago these networks were either tightly-coupled humans loosely supported by machines -- like our ballistic missile system engineering organization, which provides technical advice to the Air Force, or tightly-coupled machines loosely controlled by humans- like the ground station for the NASA Tracking and Data Relay Satellite System. Because we have been producing first-of- a kind systems like these since the early 1950s, we consider ourselves leaders in the social art of assembling effective teams of diverse experts, and in the engineering art of conceiving and developing networks of interacting machines. But in the mid-1970s we began building systems in which humans and machines must be tightly coupled to each other-systems like the Sensor Data Fusion Center. Then we found that our well-worked system development techniques did not completely apply, and that our system engineering handbook needed a new chapter on communication between people and machines. We're still writing that chapter, and it won't be finished until we can add some not-yet fully developed artificial intelligence techniques. Nevertheless, we learned some lessons worth passing along.