Low-dose chest computed tomography (LDCT) inherently captures both pulmonary and cardiac structures, offering a unique opportunity for joint assessment of lung and cardiovascular health. However, most existing approaches treat these domains as independent tasks, overlooking their physiological interplay and shared imaging biomarkers. We propose an Explainable Cross-Disease Reasoning Framework that enables interpretable cardiopulmonary risk assessment from a single LDCT scan. The framework introduces an agentic reasoning process that emulates clinical diagnostic thinking-first perceiving pulmonary findings, then reasoning through established medical knowledge, and finally deriving a cardiovascular judgment with explanatory rationale. It integrates three synergistic components: a pulmonary perception module that summarizes lung abnormalities, a knowledge-guided reasoning module that infers their cardiovascular implications, and a cardiac representation module that encodes structural biomarkers. Their outputs are fused to produce a holistic cardiovascular risk prediction that is both accurate and physiologically grounded. Experiments on the NLST cohort demonstrate that the proposed framework achieves state-of-the-art performance for CVD screening and mortality prediction, outperforming single-disease and purely image-based baselines. Beyond quantitative gains, the framework provides human-verifiable reasoning that aligns with cardiological understanding, revealing coherent links between pulmonary abnormalities and cardiac stress mechanisms. Overall, this work establishes a unified and explainable paradigm for cardiovascular analysis from LDCT, bridging the gap between image-based prediction and mechanism-based medical interpretation.

Charges against an American influencer and teen pilot who has been stranded on a remote island in the Antarctic since June have been dropped. Ethan Guo, 19, is alleged to have illegally landed his plane in Chilean territory after embarking on a solo trip to all seven continents to raise money for cancer research, according to local authorities. They accused him of providing false flight plan information to officials who detained him and opened an investigation. A judge has ordered him to leave the area, pay a $30,000 (£22,332) donation to a children's cancer foundation and is banned from re-entering Chilean territory for three years. Mr Guo made headlines last year when he began an attempt to become the youngest person to fly solo to all seven continents and collect donations for research into childhood cancer.

Protein design with desirable properties has been a significant challenge for many decades. Generative artificial intelligence is a promising approach and has achieved great success in various protein generation tasks. Notably, diffusion models stand out for their robust mathematical foundations and impressive generative capabilities, offering unique advantages in certain applications such as protein design. In this review, we first give the definition and characteristics of diffusion models and then focus on two strategies: Denoising Diffusion Probabilistic Models and Score-based Generative Models, where DDPM is the discrete form of SGM. Furthermore, we discuss their applications in protein design, peptide generation, drug discovery, and protein-ligand interaction. Finally, we outline the future perspectives of diffusion models to advance autonomous protein design and engineering. The E(3) group consists of all rotations, reflections, and translations in three-dimensions. The equivariance on the E(3) group can keep the physical stability of the frame of each amino acid as much as possible, and we reflect on how to keep the diffusion model E(3) equivariant for protein generation.

In this study, we introduce the DriveEnv-NeRF framework, which leverages Neural Radiance Fields (NeRF) to enable the validation and faithful forecasting of the efficacy of autonomous driving agents in a targeted real-world scene. Standard simulator-based rendering often fails to accurately reflect real-world performance due to the sim-to-real gap, which represents the disparity between virtual simulations and real-world conditions. To mitigate this gap, we propose a workflow for building a high-fidelity simulation environment of the targeted real-world scene using NeRF. This approach is capable of rendering realistic images from novel viewpoints and constructing 3D meshes for emulating collisions. The validation of these capabilities through the comparison of success rates in both simulated and real environments demonstrates the benefits of using DriveEnv-NeRF as a real-world performance indicator. Furthermore, the DriveEnv-NeRF framework can serve as a training environment for autonomous driving agents under various lighting conditions. This approach enhances the robustness of the agents and reduces performance degradation when deployed to the target real scene, compared to agents fully trained using the standard simulator rendering pipeline.

Numerical lattice quantum chromodynamics (QCD) is an integral part of the modern particle and nuclear theory toolkit [1-9]. In this framework, the discretized path integral is computed using Monte Carlo methods. Computationally, this is very expensive, and grows more so as physical limits of interest are approached [10-12]. Consequently, algorithmic developments are an important driver of progress. For example, resolving topological freezing [12-14]--an issue that arises in sampling gauge field configurations with state-of-the-art Markov chain Monte Carlo (MCMC) algorithms like heatbath [15-19] or Hybrid/Hamiltonian Monte Carlo (HMC) [20-22]--would provide access to finer lattice spacings than presently affordable. To such ends, recent work has explored how emerging machine learning (ML) techniques may be applied to lattice QCD [23, 24]. Of particular interest has been the possibility of accelerating gauge-field sampling [25-34] using normalizing flows [35-37], a class of generative statistical models with tractable density functions. In this framework, a flow is a learned, invertible (diffeomorphic) map between gauge fields. Abstractly, flows may be thought of as bridges between different distributions over gauge fields (or, equivalently, different theories or choices of action parameters).

Can computers perceive the physical properties of objects solely through vision? Research in cognitive science and vision science has shown that humans excel at identifying materials and estimating their physical properties based purely on visual appearance. In this paper, we present a novel approach for dense prediction of the physical properties of objects using a collection of images. Inspired by how humans reason about physics through vision, we leverage large language models to propose candidate materials for each object. We then construct a language-embedded point cloud and estimate the physical properties of each 3D point using a zero-shot kernel regression approach. Our method is accurate, annotation-free, and applicable to any object in the open world. Experiments demonstrate the effectiveness of the proposed approach in various physical property reasoning tasks, such as estimating the mass of common objects, as well as other properties like friction and hardness.

In this thesis, we investigated the relevance, faithfulness, and succinctness aspects of Long Form Question Answering (LFQA). LFQA aims to generate an in-depth, paragraph-length answer for a given question, to help bridge the gap between real scenarios and the existing open-domain QA models which can only extract short-span answers. LFQA is quite challenging and under-explored. Few works have been done to build an effective LFQA system. It is even more challenging to generate a good-quality long-form answer relevant to the query and faithful to facts, since a considerable amount of redundant, complementary, or contradictory information will be contained in the retrieved documents. Moreover, no prior work has been investigated to generate succinct answers. We are among the first to research the LFQA task. We pioneered the research direction to improve the answer quality in terms of 1) query-relevance, 2) answer faithfulness, and 3) answer succinctness.

The expedition to find the wreck of Sir Ernest Shackleton's Endurance is set to sail next month, it was announced today on the centenary of the polar explorer's death. Endurance was one of two ships used by the Imperial Trans-Antarctic expedition of 1914–1917, which hoped to make the first land crossing of the Antarctic. Carrying an expedition crew of 28 men, the 144-foot-long Endurance was a three-masted schooner barque sturdily built for operations in polar waters. Aiming to land at Vahsel Bay, the vessel became stuck in pack ice on the Weddell Sea on January 18, 1915 -- where she and her crew would remain for many months. In late October, however, a drop in temperature from 42 F to -14 F saw the ice pack begin to steadily crush the Endurance, which finally sank on November 21, 1915.

In this paper we provide a comprehensive introduction to knowledge graphs, which have recently garnered significant attention from both industry and academia in scenarios that require exploiting diverse, dynamic, large-scale collections of data. After a general introduction, we motivate and contrast various graph-based data models and query languages that are used for knowledge graphs. We discuss the roles of schema, identity, and context in knowledge graphs. We explain how knowledge can be represented and extracted using a combination of deductive and inductive techniques. We summarise methods for the creation, enrichment, quality assessment, refinement, and publication of knowledge graphs. We provide an overview of prominent open knowledge graphs and enterprise knowledge graphs, their applications, and how they use the aforementioned techniques. We conclude with high-level future research directions for knowledge graphs.

NASA has spotted a gigantic new iceberg three times the size of Manhattan in Antarctica. Named B-46, it is believed to measure 66 square nautical miles (87 square miles), according to estimates from the U.S. National Ice Center. NASA's Operation IceBridge flight spotted the giant berg, which broke off from Pine Island Glacier in late October. Wednesday's flight plan took the IceBridge team over Pine Island Glacier as part of the long-running campaign to collect year-over-year measurements of sea ice, glaciers, and critical regions of Earth's ice sheets. 'As NASA's DC-8 flew its pre-determined flight pattern, the new iceberg that calved in late October came into view,' the Space Agency said.